Akira Shiraishi, a young high school boy with feminine features, joins Blaue Rosen, the all-girl band that Mizuki Sakurazaka, an androgynous girl of the same age, performs lead electric guitar in.

Their high school life is anything but typical: Mizuki is the "prince" of her all-girl school while Akira is the "princess" of the neighboring all-boy school. A series of comical events brings them closer together, even as the prejudice of the people around them tries to pull them apart.